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BEAS-2B cells were cultured in DMEM basic nutrient solution supplemented with 10% fetal calf serum, 2 mM L-glutamine, and 100 units/ml PenicillinStreptomycin, and were maintained in a CO 2 incubator at 37 C with 5% CO 2 (v/v) (Thermo scientific, China)

Multiple imputation was utilized to appropriately handle missing values, assumed to be missing at random

Open your phone, and youll see just about any burgeoning star sharing a cig: Rachel Sennott with the cast of I Love LA , Charli xcx with platters of cigarettes at her wedding, Gabby Windey looking mother as she balances a stick between her lips, Addison Rae pink-winged and smoke-lipped, Alex Consani smearing the yellow stub with red lipstick, Hudson Williams and Connor Storrie casually and not-so-casually smoking on the street