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In contrast, nonsmokers exposed to secondhand smoke might test positive at much lower levels, but most tests are calibrated to avoid false positives from brief exposure

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Tyler Piccotti joined the Biography.com staff as an Associate News Editor and is now the News and Culture Editor

figure 10) is described as an advancing form of leukoplakia that starts as a flat, hyperkeratotic white patch and progresses to a verrucous or papillary form and then finally to invasive squamous cell carcinoma.12 PVL has a gender predilection, with a female to male ratio of approximately 4:1, a mean age of 66 years, and a site preference for the buccal mucosa, palate, tongue, and gingivae.12 Conventional risk factors are unknown

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