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It can speed up your heart rate, raise your blood pressure, and even affect your brain
This surprised Bancroft who had compared his extract from the first batch of pituri to nicotine and found the pituri extract to be much more toxic than nicotine, a finding confirmed in 1880 in experiments performed by Liversidge in Sydney on some new Duboisia hopwoodii specimens, and supported by an 1882 report that described Aboriginal hunters in central Australia steeping the leaves of Duboisia hopwoodii in waterholes to stupefy prey that drink the water, and other reports describing cattle, sheep and camels which ate it dying
10.1038/sj.npp.1301563 90
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