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[201] [202] Natural analogues [edit] Natural analogues of nicotine, often found in plants or other biological sources, include anabasine (from Anabasis aphylla), anatabine (from tobacco), arecoline (from betel nut), cotinine (major metabolite of nicotine), cytisine (from Laburnum species), and epibatidine (from frog skin), among others

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Research studies in adults have found the amount of nicotine from e-cigarettes is in varying doses ranging from slight to as large.[14] Evidence from several decades has demonstrated nicotine as a highly addictive chemical compound that can change the way the brain works and cause physical and psychological dependence