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The variability in the subjective evaluation of aerosols by users, as well as factors influencing discrepant interlaboratory levels of emissions, are significant current issues in the e-cigarette field that require extensive further study, the authors concluded

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[150] TSNAs N -nitrosonornicotine (NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N-nitrosoanabasine, and nitrosoanatabine were detected in five e-liquid samples from two companies at levels comparable to other nicotine replacement products

Consequentially, some jurisdictions have adopted a more lenient stance, differentiating between e-cigarettes and traditional tobacco products