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Additionally, presynaptic dopamine released both subcortically and within the frontal regions of the brain are influenced by inhibitory GABA interneurons, therefore disruption in GABA signaling via NMDAR abnormalities has also been linked to abnormalities in dopamine signaling (73, 90, 91)

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The high level of nicotine may lead to higher rates of nicotine dependence among users, particularly young people

Cannabis and cognitive performance in psychosis: a cross-sectional study in patients with non-affective psychotic illness and their unaffected siblings

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