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Methods To determine the impacts of several events, such as the e-cigarette and vaping-associated lung injury (EVALI) outbreak and implementation of the Massachusetts e-cigarette tax, on e-cigarette and cigarette purchasing, we conducted an interrupted time-series analysis of year-on-year consumer purchasing data to impute changes in e-cigarette and cigarette purchasing in the Greater Boston area and the entire USA after several intervention points

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Supplementary file Table 4 provides a summary of potential mechanisms to enhance the motivation underlying different interventions, including improving the efficacy of smoking cessation, reducing the relapse rate, developing new habits, and alleviating nicotine withdrawal symptoms

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