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[828] We project that 69.93 percent of MIPS eligible clinicians will receive a positive adjustment in our baseline model and 77.51 percent of MIPS eligible clinicians will receive a positive adjustment in our proposed policies model

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This may be explained by the possible DNE and GOF effects of non-disruptive mutant p53 proteins that lead to increased proliferation, metastasis and chemo-resistance, whereas disruptive p53 mutations are unlikely to exert DNE and GOF effects [167]