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Nicotine seems to alternate between acting as a stimulant and a depressant

[17] Vascular Function There are ample published data documenting that chronic exposure to tobacco smoke leads to a pathological alteration of endothelial function

The Impact of Tax or Price Measures on Smoking Onset and Cessation in Nigeria

Embracing the potential for less harm is significantly more effective than the insistence on nicotine abstinence that has traditionally dominated cigarette cessation efforts in public health and regulation