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Treg cells from Gpr15 +/+ mice conferred substantial protection, whereas those from Gpr15 / mice were ineffective, indicating that smoking enhances the suppressive function of Tregs through Gpr15 (Supplementary Fig

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Furthermore, GSK343 pretreatment of 16HBE and A549 cell line stimulated with CSE greatly increases the expression of DAB2IP compared to untreated cells