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Alcohol metabolizes into acetaldehyde, a toxic and carcinogenic substance that, together with tobacco carcinogens, significantly increases the likelihood of developing esophageal squamous cell carcinoma

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In 2019, an outbreak of e-cigarette or vaping product use-associated lung injury (EVALI) hospitalised thousands of people, though this was primarily linked to illicit THC/cannabis products containing vitamin E acetate, not regulated nicotine vapes

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