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embargo on Cuban products is likely one of the biggest causes

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(See Gold Derby's career retrospective interview with Mike Flanagan.) The initial pitch went nowhere, but Flanagan persisted, taking his idea to Gunn and Safran after they assumed control of DC's film unit, and selling them on a stand-alone body-horror movie in the vein of classic David Cronenberg

2 with age on the horizontal axis and each birth cohort represented by a line (Additional file 1: Figure S3), providing a complementary perspective of the smoking epidemic in the high-income regions