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The microRNA-10b targeted therapeutic, TTX-MC138, is effective in preclinical pancreatic adenocarcinoma

HTT, in contrast, showed a much higher toxicity effect on all cell types (IC 50 = 3 nM, 20 nM, and 40 nM for SF8628, KISPIDMG-105, and BBB)

10.7326/0003-4819-143-7-200510040-00009 Ann

[DOI] [PubMed] [Google Scholar] Zeng X

This protective effect extended to other stressors, as glutathione amino acid precursors also shielded cells from blue light-induced ROS production and pollutant-induced ATP depletion, demonstrating a broad-spectrum protective action