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We found that many of the studies were at high risk of bias this was usually because the e-cigarette users under investigation were also current or previous tobacco smokers (or studies had not checked for this), making it hard to pick out the effects of the e-cigarettes alone the findings should be considered with this in mind

Notable differences between the online (convenience sample) and household (more representative sample) survey respondents have been identified, particularly in their demographic characteristics and smoking behavior

The place went under, but the scene still stayed

We used an adaptive design, which means that part-way through data collection, an interim analysis was conducted to assess how many more participants would need to be recruited for the study to have enough statistical power to detect an effect of pack size

This might lead vapers to take more puffs or vape for longer sessions to achieve the desired level of satisfaction