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*Source: Journal Addictive Behaviours, Nov 2006
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[9] Thin upper lip Smooth hypoplastic philtrum Down-slanting, short palpebral fissures Hypertelorism Microcephaly Epicanthal folds Receding chin Features of specific systemic defects Heart defects (mainly ventricular septal defect) Heart-lung fistulas Skeletal anomalies (limb dislocations, joint contractures, pectus excavatum/pectus carinatum) Holoprosencephaly: a developmental field defect in which the forebrain fails to divide into two hemispheres, resulting in fusion of ventricles (leading to the formation of monoventricle) and other bilateral cerebral structures, e.g., basal ganglia
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