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Electrochemotherapy (ECT) synergistically combines PEFs with chemotherapeutic agents: drugs are administered intratumorally before PEFs application, where transient membrane permeabilization enhances intracellular drug uptake, significantly potentiating cytotoxicity against treatment-resistant malignancies

The method of any one of embodiments 118-138, wherein the composition is free or substantially free of water, C1-C6 alcohols or C1-C6 glycols, C1-C4 alcohols or C1-C4 glycols, or any combination thereof

These enzymes can fine-tune intracellular TH concentrations independently of systemic levels [16,17,18]

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Third, the stability window