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Thus, further research is key to improve understanding of the underlying mechanisms of AD and develop more effective therapies

Robinson MM, McBryant SJ, Tsukamoto T, Rojas C, Ferraris DV, Hamilton SK, Hansen JC, Curthoys NP

Age-related macular degeneration Age-related macular degeneration (AMD) is the primary cause of blindness among older adults in industrialized countries

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Although they are inhibited by GPX4 inhibitors such as RSL3 in vitro , treatment of cells with more specific TrxR inhibitors, e.g., TRi, does not induce ferroptosis [102] indicating that TrxR is not directly involved in ferroptosis