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Airborne Gram-negative bacterial endotoxin and fungal-derived glucans have been shown to cause acute and chronic respiratory effects in occupational and environmental settings, says senior author and professor David Christiani

The competitive landscape is led by established players such as PT Gudang Garam Tbk, PT HM Sampoerna Tbk (Philip Morris International subsidiary), PT Djarum, PT Bentoel Internasional Investama Tbk, and Nojorono Tobacco Indonesia, which collectively control a major share of global kretek production

Oral corticosteroids have a high rate of success in treating flare-ups of symptoms

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Over-the-counter pain relievers may also help reduce inflammation and discomfort