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Figure 1 Flowchart for data filtering, UK Biobank, 20062020 (N=502411) Outcome data Association of smoking status with the likelihood of AP, CP, and PC The odds for AP, CP, and PC for never smokers, ex-smokers, and current smokers are shown in Table 2

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In the CS + OM group, cytokine expression increased and decreased gradually until day 10

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Despite some evidence that E-cigarette vaping may be safer than smoking traditional cigarettes 18,19 , their safety profiles remain to be fully characterized and there is a growing body of evidence highlighting the deleterious effects of vaping 20,21,22