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LIN28 regulates stem cell metabolism and conversion to primed pluripotency

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Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer

By genetically deleting the disulfide reductase pathways from mouse liver, we uncovered an inducible, ubiquitous, cell-autonomous reductase-independent backup pathway for the generation of cysteine, driven by cystine CS bond cleavage

For example, peptides and proteins like insulin may require a slightly acidic environment (pH 4.05.5) to remain stable, whereas drugs such as atropine tend to be more stable in a slightly basic environment (pH 7.58.5)