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In a pilot trial of NAD+ intravenous infusion in healthy adults, subjects receiving 750 mg of NAD+ over 6 hours reported no negative symptoms at all, and there were no vital sign abnormalities or serious laboratory derangements compared to placebo

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If this mechanism can be harnessed for long-lasting modulation, then CRF 1 antagonists, serving as antidepressant, present new potential for application

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