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Neuropeptide signalling proteoforms derived from VGF, somatostatin (SST) and protachykinin-1 (TAC1) showed higher abundance in AD-resilient than AD-dementia brain, whereas signalling proteoforms of cholecystokinin (CCK) and chromogranin (CHG) A/B and multiple cytoskeletal molecules were enriched in frail vs control brain

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As seen in the preclinical results, GSH was at a 4-fold reduction in theT2DM group when compared to the healthy group, therefore supplementing with L-GSH can maintain GSH levels, decrease the levels of oxidized GSH, decrease the levels of the proinflammatory cytokine IL-6 and other oxidative stress markers in individuals with diabetes