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In response to these challenges identified with the self-medication hypothesis, researchers have developed an alternate theory to explain the heightened prevalence of smoking in SZ which is termed the addiction vulnerability hypothesis (43)

The more one smokes, the more tobacco is required to achieve the same level of relief and substantial pleasure, leading to increased consumption and dependency

The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism

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