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Ferroptosis, a distinct form of cell death, plays a crucial role in inhibiting tumor growth and has opened new avenues for treating chemotherapy-resistant tumors

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Loss of intracellular GSH is likely multifactorial and includes generation of high levels of hydroperoxy-phospholipids (which directly or indirectly oxidize GSH and limit GSSG recycling by reductases) as well as active export of GSSG generated by high GPX4 activity (7, 8, 21)

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