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Specifically, when a boy is exposed to tobacco smoke, it may cause epigenetic changes to his germ cells

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[48] Some people use e-cigarettes while continuing to smoke conventional cigarettes(dual use), for example during quit attempts or in situations where smoking is restricted

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This difference in legal status is striking, considering that the nicotine found in tobacco has been cited as one of the most addictive substances in the world, alongside heroin, cocaine, barbiturates, and alcohol