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While the exogenic sources of ROS consist of environmental factors such as smoking [99], alcohol use [100], and air pollutants [101], leukocytes (neutrophils and macrophages) are the main endogenic source of ROS [102], although immature spermatozoa contribute as well [103]

Then , the Food and Drug Administration won regulatory control over the tobacco industry that led to the limiting of sale of branded merchandise, the banning of sports and entertainment sponsorships, and youth market targeting

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In atheromatous plaques, the accumulation of vascular smooth muscle cells (VSMCs) have a phenotype differing from that of their normal contractile type