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The peptide selectively targets cells that have already undergone senescence as a consequence of earlier chemotherapy exposure, demonstrating a favorable safety profile for potential clinical application

46,47,48 In 2005, the discovery of pseudouridine () modification addressed the immunogenicity issue of in vitro-synthesized mRNA, 49 leading to the initiation of the first human trial of an mRNA vaccine against melanoma in 2008

Secondly, studies on the mechanism of synergistic anti-tumor effect need to be further elucidated, particularly on contributions by different signaling pathways

Oxidative stress can damage blood vessels, leading to serious heart problems

333,334,335,336 They have been considered good candidates for NADs delivery