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Taken together with the findings that utilization of esketamine as an antidepressant increases LAC levels [59], the fact that the decrease in LAC levels in subjects with MDD is independent of psychotropic drug treatment raises the possibility that increasing LAC levels may be needed to induce antidepressant effects

This isn't just a matter of semantics

It's a milder form of pneumonia that doesn't often lead to hospitalization, but can still lead to serious issues like meningitis and encephalitis