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A pharmacokinetic (PK) and pharmacodynamic (PD) analysis of the antioxidants used in these trials suggests that many inconclusive results may reflect pharmacokinetic limitations rather than true pharmacodynamic inefficacy
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Design,Synthesis and Biological Evaluation of Novel Androst-3, 5-diene-3-carboxylic Acid Derivatives as Inhibitors of 5-Reductase Type 1 and 2.Steroids.2017,124, 29-34 71