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Rebecca Craft, a psychologist researching cannabis and the endocrine system at Washington State University, Several pieces of evidence point to estrogens estradiol in particular, which is the major estrogenic hormone in both rats and humans as the hormone that makes females more sensitive than males to some effects of THC. In researching male rats with their testes removed and then treated with estradiol, their sensitivity to THCs pain-relieving effects started to resemble that of female rats