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These combined effects make the development of DSIP a promising aid for individuals struggling with long-term pain management (5)

It has been reported that at least two DAMPs, namely mutant KRAS protein [172] and the DNA oxidation product 8-hydroxyguanosine/8-OHG [37], are released by ferroptotic cells to mediate macrophage polarization through the activation of AGER/RAGE (advanced glycosylation end-product specific receptor) and STING1/STING/TMEM173 (stimulator of interferon response cGAMP interactor 1) pathways, respectively

16(3):BR81-88

PMID: 24747001

Inhibition of T-Cell proliferation by Helicobacter pylori -glutamyl transpeptidase