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"Because e-cigarettes contain nicotine, there could also be an association with depression," Obisesan said

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Some depressants can get addictive because they induce a sense of euphoria in users

In theory, a 42.7% decline in cigarette sales caused by smokers switching to iQOS could eventually result in 90,400 fewer deaths, if iQOS was harmless, or over 80,00 if iQOS carries 10% of the health risk of smoking