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timonensis are rare populations among gut microbial community with relative abundance of around 0.01% or less, however, the significance of rare species to specific biological function might still be considerable in a diverse ecological system [29]

This group is also more likely to be magnesium deficient (see figure 7), probably due to the Western diet, high in calcium and low in magnesium

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For context on how peptides can have systemic effects, the TB-500 (Thymosin Beta-4) research provides a comparative look at another peptide with immune-relevant properties

Community sources variously attribute it to dose, to the DMSO carrier in transdermal use, or to vascular effects, with no way to confirm cause in self-reports