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First, by enhancing fatty acid transport into the mitochondria, it theoretically ensures that a greater proportion of the energy deficit is filled by fat oxidation rather than muscle protein breakdown

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Use objective checkpoints when available (exam findings, ultrasound or MRI in appropriate cases)

Taken together, the in-vivo E-peptide literature partially rehabilitates the idea that the E-domain does something, while simultaneously demolishing the simplistic version of the story: the effects are context-dependent, age-dependent, only partly receptor-independent, and not unambiguously beneficial even in mice