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Tobacco smoke has been shown to inhibit CYP2A6, leading to a decrease or at least a slowdown in nicotine metabolism in smokers compared to non-smokers ( Nicotine not only serves as a substrate for metabolizing enzymes and drug transporters, but also appears to alter their activity

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He also was honored as AP male athlete of the year, and his feat in Beijingbreaking Mark Spitzs 36-year-old record for most gold medals in an Olympicswas chosen as the top story of 2008