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Beyond validating the model parameters, we also ran a number of sensitivity analyses with restrictions on the included data points

Italian excise duty applies (22/kg as of 2023), but because pouches are shipped from within the EU, customs complications for personal orders are minimal

Smokers in China are mostly male, while only 2.4% of women smoke regularly compared with 63% of middle aged men 4564 years of age [ 32 ]

The United States and Australia were the countries or regions that received the most funding and conducted extensive research on smoking cessation (Supplementary file Figure 1)

In Pima County, about 1 in 20 adolescents reported having ever smoked a cigarette and at least 3 in 20 having used a vape at least once