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The activation promotes angiogenesis and improves blood flow to damaged, hypovascular tissues (tendons and ligaments)

One study, which also evaluated cognitive function in patients with high MMA concentrations, found no significant effects on the MDD inventory score, but only 30 of the 140 subjects had depression at baseline, which may have diluted any benefits

The body requires time to replenish depleted stores, regenerate red blood cells, and repair neurological damage caused by prolonged deficiency

This proposed synergy and the specific doses here are not clinically validated , and neither compound has approved human use