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It happens when there arent enough red blood cells to carry oxygen throughout the body, whether because your body isnt making enough of them or because they are damaged in some way due to factors that include abnormal hemoglobin or being deficient in iron, which is needed to make hemoglobin

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Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 2010, 64 (4):247-251

Airway narrowing and tissue destruction leave smokers struggling to breathe, leading to conditions like emphysemaa long-term consequence of this respiratory battle

Also, e-cigarette makers will have to go back to the agency within two years for approval of the products they already sell