Surgeon General published a seminal report, Smoking and Health: Report of the Advisory Committee to the Surgeon General of the Public Health Service , confirming causal links between smoking and cancer
Then, the appearance in 2023 of 6MN in commercial vaping systems began the current era, that of tobacco , nicotine , and nicotine analog control
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Compared with quitting smoking completely, use of heated tobacco products had more consistently harmful effects
The direct effect of being a current smoker, and via the increased risk of long-standing comorbidities