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Although no significant changes in the dermal thickness was observed in histology, the dermal layer alterations of the skin substitutes were investigated since the dermis, being a nonproliferating layer, is generally greatly affected by the extrinsic aging process

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However, MRSA is a clonal pathogen and the net result of numerous large epidemiological studies has highlighted a number of predominant clones that are responsible for the majority of the global prevalence of MRSA and subsequent disease burden 30,31,32