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[17] found that transcriptional factors Snail1 and Twist were upregulation and nuclear translocation in smokers and current-smoking COPD, and their expression is closely associated with EMT activity (S100A4 expression) and the levels of airflow obstruction

Policy Rationale: Bills aim to deter youth nicotine use but data show record-low smoking rates among both youth and adults

"Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: a systematic review"

Many users gradually reduce nicotine levels over time, eventually reaching very low concentrations or even nicotine-free options