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Our previously used concentrations of sertraline in pre-clinical in vivo experiments with anti-cancer effects can be extrapolated to the concentrations used in humans, showing a therapeutic index of sertraline that could support future clinical trials [19, 23, 24]

Together, these in vivo and in vitro data suggest that an NAD + precursor such as NMN may be safe to use in the context of cancer, as a strategy to reduce the impact of cytotoxic chemotherapy on female fertility, without impairing cancer treatment

doi: 10.3892/mmr.2017.7398 7 RaffaelliRGarzonSBaggioSGennaMPominiPLaganASet al