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Disturbed efferocytosis with abnormal accumulation of apoptotic epithelial cells in the airway lumen has been conclusively documented in COPD patients [216]

The reduced digestive impact of NRTs likely results from: Lower peak nicotine levels compared to cigarettes or snus More gradual nicotine absorption rates Absence of additional tobacco compounds that may affect digestion Steady release formulations (especially patches) that prevent nicotine spikes For people quitting smoking who are concerned about constipation, transitioning through nicotine pouches or gum before eliminating nicotine completely might help manage digestive changes more comfortably

They primarily infest pantries and garages