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Set: 1910 T206 Subject: Clyde Engle Subset: Sweet Caporal 350 Grader: SGC Grade: 1 Certification #: 0099077 Team: New York Amer

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In addition, IL-6 induces the overexpression and nuclear translocation of transcription factor STAT-3 through trans- signaling, which results in T-cell resistance to apoptosis by inducing the expression of the anti-apoptotic factors bcl-2 and bcl-xl