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In addition, by blocking the ability of nicotine to activate 4 2 nicotinic acetylcholine receptors, varenicline inhibits the surges of dopamine release that are believed to be responsible for the reinforcement and reward associated with smoking
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Some of the most addictive substances are prescribed legally prior to being abused, and some are illegal street drugs
Currently, for non-tobacco nicotine products (i.e., those using synthetic nicotine) to be marketed legally, they must also get pre-market FDA authorization