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There is good evidence, but not with absolute certainty, that the smoke with the more cancer-causing agents gets deeper to the lungs where adenocarcinomas more commonly occur. Efforts to contact major tobacco companies and industry groups for comment on this study were not successful

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Among the studies that do analyze doseresponse relationships, there is large variation in the units and dose categories used in reporting their findings (for example, the use of pack-years or cigarettes per day) 24,25 , which complicates the comparability and consolidation of evidence

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