tobacco was considered a poor man's crop because Tobacco: The Most Versatile Cash Crop Big Tobacco's Environmental Impact Is

The inhalation calculations are based on previous referenced studies in which mice were exposed to cigarette smoke, the researchers concluded that the nicotine dosage in two fifteen-minute vapour exposures is equivalent to smoking two tobacco cigarettes twice daily

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The drydown is where this gets a bit darker

In 1798 the US physician Benjamin Rush wrote on the medical dangers of tobacco

Keep your doors and windows closed, whenever not required