At the genomic level, Epitalon modulated the expression of key circadian rhythm genes: Clock expression in leukocytes decreased 1.8-fold, Cry2 expression doubled, and Csnk1e expression in lymphocytes decreased by 2.1-fold, all with statistical significance
Mechanistically, UA enhances mitochondrial -oxidation and potentially activating skeletal muscle adenosine 5-monophosphate-activated protein kinase (AMPK) signaling and upregulating mitochondrial respiratory chain complex activity to exert ergogenic effects
& Higgins, J
These methods allow for tracking the brains return to normal serotonin levels and evaluating improvements in mood and cognitive functions, which are indicative of serotonin recovery
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