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For example, the LD50 (lethal dose 50%) test, which is typically performed on mice, rats, pigeons, quail and fish, involves determining the dose of a substance (such as a pesticide) that kills (or would lead to the death of) 50% of the animals tested
Moreover, studies confirm that nicotine vapes and cigarettes are economic substitutes.[34][35][36][37][38] This means that any increase in cigarette prices tends to boost vape sales, while raising vape prices often pushes users back to smoking
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that is replacing high-risk cigarettes with less risky alternatives