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One particular substance, coumarin, was a known carcinogen, but Brown & Williamson was using it in pipe tobacco to provide flavoring

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The added chemicals from the leaves then dry out and irritate the mouth, further irritating your mouth

The rebellion fell apart when Bacon died of dysentery, but the authorities recognized the danger of continuing to award land grants to indentured servants who might then use their resources to fund revolt and so ended that policy